Contents
How do you synthesis acetanilide?
Acetanilide is prepared from aniline when it reacts with acetic anhydride/glacial acetic acid in the presence of zinc dust. A mixture of aniline, glacial acetic acid, acetic anhydride and zinc dust is refluxed under anhydrous condition and then poured the mixture into ice cold water to get acetic anhydride precipitate.
What are the products in the synthesis of acetanilide?
In this particular synthesis, an aromatic 1° amine (aniline) will combine with a carboxylic acid anhydride (a functional group which we have not yet studied) to produce an aromatic N-substituted amide (acetanilide) and a carboxylic acid (acetic acid).
What is the formula of acetanilide?
C8H9NO
Acetanilide/Formula
Why Acetic acid is used in synthesis of acetanilide?
Beside above, why glacial acetic acid is used in preparation of Acetanilide from aniline? Glacial acetic acid is used because it is an excellent polar protic solvent capable of dissolving acetanilide. For the process, acetanilide is first dissolved in the solvent, glacial acetic acid, by warming.
Why is the synthesis of acetanilide still relevant?
Acetanilide is also a building block in the synthesis of penicillin, an important antibiotic. When acetanilide is reacted with chlorosulfonic acid (HSO3 Cl), it produces 4-acetamidobenzenesulfonyl chloride, which is then reacted with ammonia or organic primary amines to make sulfonamides.
Why is acetanilide no longer used as a drug?
In the body acetanilide is mostly converted to acetaminophen, which has replaced acetanilide in therapy because it is less likely to induce blood disorders.
What type of drug is acetanilide?
Acetanilide, synthetic organic compound introduced in therapy in 1886 as a fever-reducing drug. Its effectiveness in relieving pain was discovered soon thereafter, and it was used as an alternative to aspirin for many years in treating such common complaints as headache, menstrual cramps, and rheumatism.
Is acetanilide a base or acid?
Acetanilide is the neutral compound in the mixture. Since it is neutral, it will not react with any inorganic base or acid.
What is the Colour of Acetanilide?
Acetanilide is slightly soluble in water, and stable under most conditions. Pure crystals are plate shaped and colorless to white.
Is Acetanilide a base or acid?
How is acetanilide synthesized from acetic anhydride?
Synthesis of acetanilide from aniline. BACKGROUND. Principle: Acetanilide is synthesized from aniline by acetylating it with acetic anhydride in presence of glacial acetic acid.