Can statin drugs cause anemia?

Abstract. Here,we report a rare adverse effect of some statins(Lovastatin, Atorvastatin)onhemolytic anemia, which was stopped after switching to Rosuvastatin.

Can statins affect red blood cells?

Statins-family of drugs are commonly prescribed for hypercholesterolemia patients with both primary and secondary prevention in order to decrease the level of the blood cholesterol. Statin drugs, thus affect RBC mechanics indirectly through modulation of cholesterol content of the membrane [6].

Do statins affect iron levels?

The proposal of the existence of a statin–iron nexus results from evidence that statins alter iron homeostasis47–56 and that both statins and lower ferritin levels appear to be effective in reducing oxidative stress and associated inflammation, resulting in improved clinical outcomes.

Can statins cause blood problems?

It’s possible your blood sugar (blood glucose) level may increase when you take a statin, which may lead to developing type 2 diabetes. The risk is small but important enough that the Food and Drug Administration (FDA) has issued a warning on statin labels regarding blood glucose levels and diabetes.

Can statins lower your white blood cell count?

The UCSD findings demonstrate that statins have important pharmacological effects beyond inhibiting cholesterol production. “We found these drugs fundamentally alter how white blood cells behave upon encountering bacteria,” Nizet said.

What are the side effects of atorvastatin?

Atorvastatin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• diarrhea.
• heartburn.
• gas.
• joint pain.
• forgetfulness or memory loss.
• confusion.

What side effects do statins cause?

Side effects can vary between different statins, but common side effects include:

• headache.
• dizziness.
• feeling sick.
• feeling unusually tired or physically weak.
• digestive system problems, such as constipation, diarrhoea, indigestion or farting.
• muscle pain.
• sleep problems.
• low blood platelet count.

Can I take atorvastatin and iron together?

No interactions were found between atorvastatin and Iron 100 Plus. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

What happens to hemoglobin when you take statins?

Macrophages typically produce heme oxygenase in order to break down hemoglobin into bilirubin and carbon monoxide, thus detoxifying the hemoglobin. So this is a strong indication that statins induce excess free hemoglobin in the blood, with the most plausible source being wrecked RBCs.

Are there any side effects to taking a statin?

With regular use, they can not only lower “bad cholesterol” ( LDL) but also triglyceride levels. They can boost your “good cholesterol” levels (HDL), too. Research has shown that the salutary effect of statins on cholesterol may not be their only benefit.

Why do statins destroy red blood cells ( RBCs )?

So this is a strong indication that statins induce excess free hemoglobin in the blood, with the most plausible source being wrecked RBCs. The macrophages in atherosclerotic plaque have been shown to avidly take up hemoglobin and break it down with heme oxygenase, with the resulting accumulation of iron deposits in the plaque.

Can a statin increase your HDL cholesterol level?

With regular use, they can not only lower “bad cholesterol” (LDL) but also triglyceride levels. They can boost your “good cholesterol” levels (HDL), too. Research has shown that the salutary effect of statins on cholesterol may not be their only benefit.