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How does Zofran stop nausea?
This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body’s natural substances (serotonin) that causes vomiting.
Is ondansetron a serotonin antagonist?
Ondansetron: a serotonin receptor (5-HT3) antagonist for antineoplastic chemotherapy-induced nausea and vomiting. DICP.
What are Ondansetron indications?
Ondansetron tablets are indicated for the prevention of nausea and vomiting associated with: highly emetogenic cancer chemotherapy, including cisplatin greater than or equal to 50 mg/m2. initial and repeat courses of moderately emetogenic cancer chemotherapy.
What are side effects of ondansetron?
Headache, lightheadedness, dizziness, drowsiness, tiredness, or constipation may occur. If these effects persist or worsen, notify your doctor promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
Why am I still nauseous after taking Zofran?
The mechanism of the drug involves blocking serotonin, which can cause vomiting. Doctors will look at your liver health and weight when deciding how much of the drug you should take. While Zofran can offer relief to some patients who can’t eat or struggle with chronic nausea, it can also create severe side effects.
What else can Ondansetron be used for?
How does ondansetron work to prevent nausea and vomiting?
Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. Ondansetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.
How does ondansetron work on the 5-HT3 receptor?
Ondansetron is a selective antagonist of the serotonin receptor subtype, 5-HT3 8, 9, 10. Cytotoxic chemotherapy and radiotherapy are associated with the release of serotonin (5-HT) from enterochromaffin cells of the small intestine, presumably initiating a vomiting reflex through stimulation of 5-HT3 receptors located on vagal afferents 8, 9, 10.
How is ondansetron different from other serotonin antagonists?
Ondansetron is a highly specific and selective serotonin 5-HT 3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors Label, 3, 4.
How is ondansetron used in the treatment of schizophrenia?
Brands include Zofran and Zuplenz. It can be given by mouth, as a tablet or orally disintegrating tablet, or by injection into a muscle or into a vein. A 2006 double-blind, randomized controlled trial indicated ondansetron may have value in the treatment of schizophrenia, as an adjunct to haloperidol.