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How is amiodarone eliminated?
Amiodarone is eliminated primarily by hepatic metabolism and biliary excretion and there is negligible excretion of amiodarone or DEA in urine. Neither amiodarone nor DEA is dialyzable.
What kind of blocker is amiodarone?
Amiodarone is a primarily a class III antiarrhythmic. Like other antiarrhythmic drugs of this class, amiodarone works primarily by blocking potassium rectifier currents that are responsible for the repolarization of the heart during phase 3 of the cardiac action potential.
Is amiodarone an AV blocker?
The AV block caused by amiodarone has been reported by some authors previously. Electrophysiologic testing in two patients with amiodarone-induced AV block revealed intra-His block.
What kind of action does amiodarone have on the heart?
Amiodarone. Amiodarone is an iodine -rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period.
What kind of aryl radical is amiodarone made of?
AM contains chemically labile iodine bonds that may be extracted to generate the highly reactive aryl radical (Li and Chignell 1987; Amiodarone has a major place in the management of both acute and chronic ventricular and supraventricular arrhythmias.
Are there any over the counter drugs that work with amiodarone?
Many drugs can interact with amiodarone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using. Remember, keep this and all other medicines out of the reach of children]
How is the maintenance dose of amiodarone determined?
-Maintenance dose should be determined according to antiarrhythmic effect as assessed by patient tolerance as well as symptoms, Holter recordings, and/or programmed electrical stimulation; some patients may require up to 600 mg/day while some can be controlled on lower doses.