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What are ACE inhibitors classified as?
The class of drugs called angiotensin converting enzyme (ACE) inhibitors, as the class name suggests, reduces the activity of angiotensin converting enzyme. ACE converts angiotensin I produced by the body to angiotensin II in the blood.
Are ACE inhibitors teratogenic?
Specifically, these drugs were associated with increased infant risks for cardiovascular and nervous system anomalies. ACE inhibitors, long known to be teratogenic when used in the last two trimesters of pregnancy, have been considered safe in the first trimester.
How does ACE inhibitor affect pregnancy?
The use of an ACE inhibitor during the second and third trimesters of pregnancy has been associated with a number of serious foetal malformations including oligohydramnios, foetal and neonatal renal failure, bony malformations, limb contractures, pulmonary hypoplasia, prolonged hypotension and neonatal death.
Why ACE inhibitors are not used in pregnancy?
It is well accepted that angiotensin-converting enzyme (ACE) inhibitors are contraindicated during the second and third trimesters of pregnancy because of increased risk of fetal renal damage. First-trimester use, however, has not been linked to adverse fetal outcomes.
Is Category C safe during pregnancy?
Category C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
When to take an ACE inhibitor during pregnancy?
Currently, ACE inhibitors are pregnancy category C in the first trimester and category D in the second and third trimesters. Most malformations identified were various cardiac septal defects. The results of this study do not establish a causal relationship.
What do you need to know about ACE inhibitors?
WHAT YOU NEED TO KNOW Currently, ACE inhibitors are pregnancy category C in the first trimester and category D in the second and third trimesters. Most malformations identified were various cardiac septal defects. The results of this study do not establish a causal relationship.
Are there any blood pressure medications that are safe for pregnant women?
Ali is also an award-winning writer. While most drugs used to treat hypertension can be taken safely in women who are pregnant, two closely related categories of blood pressure medication should be avoided. These are angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blocker (ARB) drugs.
How are angiotensin converting enzyme inhibitors ( ACEi ) used?
Angiotensin Converting Enzyme Inhibitors (ACEI) – StatPearls – NCBI Bookshelf ACE inhibitors are medications used in the treatment and management of hypertension, which is a significant risk factor for coronary disease heart failure, stroke, and a host of other cardiovascular conditions.