Contents
What causes Carcinosarcoma of the uterus?
Both neoplasms are associated with obesity, nulliparity, and use of exogenous estrogen and tamoxifen. In addition, a history of exposure to pelvic radiation seems to be associated with an increased risk of developing uterine carcinosarcoma [2].
Is Carcinosarcoma hereditary?
Conclusion: The loss of MLH1 protein expression suggests the germline mutation contributed to the development of the carcinosarcoma. Hereditary nonpolyposis colorectal cancer should be included in the differential diagnosis of persons with uterine carcinosarcoma when noted within a family history suspicious for HNPCC.
What does Carcinosarcoma mean?
Listen to pronunciation. (KAR-sih-noh-sar-KOH-muh) A malignant tumor that is a mixture of carcinoma (cancer of epithelial tissue, which is skin and tissue that lines or covers the internal organs) and sarcoma (cancer of connective tissue, such as bone, cartilage, and fat).
What kind of cancer is a carcinosarcoma?
Carcinosarcomas are malignant tumors that consist of a mixture of carcinoma (or epithelial cancer) and sarcoma (or mesenchymal / connective tissue cancer). Carcinosarcomas are rare tumors, and can arise in diverse organs, such as the skin, salivary glands, lungs, the esophagus, pancreas, colon, uterus and ovaries.
How long does it take for carcinosarcoma to develop?
Specifically, carcinosarcomas have been reported to occur 7–20 (median of 9 years) years after the initiation of this regime. On the contrary, oral contraceptives are reported to provide a protective effect against these tumors.
Is there such a thing as gyn carcinosarcoma?
Another Term for GYN Carcinosarcoma is malignant mixed Müllerian tumor or MMMT. GYN carcinosarcoma is a malignant neoplasm found in the uterus, the ovaries, the fallopian tubes and other parts of the body that contains both carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components.
Which is the best treatment for carcinosarcoma?
The current primary treatment option remains surgery; however, high rates of relapse and metastases postoperatively necessitate effective adjuvant therapies such as chemotherapy.