What is biotransformation process?

Biotransformation is a process by which organic compounds are transformed from one form to another to reduce the persistence and toxicity of the chemical compounds. This process is aided by major range of microorganisms and their products such as bacteria, fungi and enzymes.

What is metabolism or biotransformation?

Biotransformation is a metabolic process that takes place mainly in the liver and helps to facilitate the excretion of both exogenous and endogenous substances. A series of reactions alter the chemical structures of these substances.

Why do drugs undergo biotransformation?

To defense the body against xenobiotic substances, an array of biotransformation reactions (or metabolic reactions) is undergone. Due to the biotransformation, the molecular structure of a drug is commonly changed to be more hydrophilic and the substances can be readily eliminated from the body [2].

What is the role of biotransformation?

Biotransformation is essential to convert lipophilic chemicals to water-soluble and readily excretable metabolites. Biotransformation also plays an essential role in the toxicity of many chemicals due to the metabolic formation of toxic metabolites.

What are examples of biotransformation?

The metabolism of a drug or toxin in a body is an example of a biotransformation. The body typically deals with a foreign compound by making it more water-soluble, to increase the rate of its excretion through the urine.

What happens in drug biotransformation?

Biotransformation means chemical alteration of chemicals such as nutrients, amino acids, toxins, and drugs in the body. It is also needed to render non-polar compounds polar so that they are not reabsorbed in renal tubules and are excreted.

What is another term for biotransformation of a drug?

What is another term for biotransformation of a drug? Metabolism.

What do you mean by biotransformation in medicine?

Biotransformation means chemical alteration of chemicals such as nutrients, amino acids, toxins, and drugs in the body. It is also needed to render non- polar compounds polar so that they are not reabsorbed in renal tubules and are excreted. Biotransformation of xenobiotics can dominate toxicokinetics and…

What are the biotransformations of Phase 2 drugs?

phase II Drugs can undergo one of four potential biotransformations: Active Drug to Inactive Metabolite, Active Drug to Active Metabolite, Inactive Drug to Active Metabolite, Active Drug to Toxic Metabolite (biotoxification).

Who is the author of pharmacokinetics and biotransformation?

Pharmacokinetics. What is biotransformation? | CME at Pharmacology Corner Pharmacokinetics. What is biotransformation? Author: Flavio Guzman, MD.

Are there other approaches to biotransformation Besides enzymatic?

Also there is other approach of biotransformation called enzymatic biotransformation. Petroleum oil is toxic for most life forms and episodic and chronic pollution of the environment by oil causes major ecological perturbations.