Contents
What is chalcone in organic chemistry?
Chalcone: A conjugated ketone in which the carbonyl group is bonded to a benzene ring on one side and an alkene on the other.
What classifies a compound as a chalcone?
Chalcone is a member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group. An aromatic KETONE that forms the core molecule of CHALCONES.
What are the uses of chalcone?
Chalcones and their analogs possess significant biological activities including antimicrobial, anticancer, antitubercular, antioxidant, anti-inflammatory, antileishmanial, enzyme inhibitory, and miscellaneous applications and hence acquire a unique place in medicinal chemistry.
What color is chalcone?
The bright yellow-colored chalcones found in many plants and in some families contribute significantly in the pigmentation of corolla. Chalcones can be synthesized in the laboratory by aldol condensation between a benzaldehyde and an acetophenone in the presence of base (Fig. 9.13) [137].
How is Benzalacetophenone formed?
Benzalacetophenone can be prepared from benzaldehyde and acetophenone, by the use of either acid1 or alkaline condensing agents. The alkaline agents are superior and those generally used are a 30 per cent solution of sodium methoxide at low temperatures2 and alcoholic sodium hydroxide.
Is chalcone soluble in water?
Solubility : Soluble in chloroform, ether, benzene, and ethanol (slightly). Insoluble in water.
How do you synthesis chalcone?
Chalcone is synthesized by Claisen-Schmidt condensation, which involves the cross-aldol condensation of aldehydes and ketones with a base or acid catalyst followed by a dehydration reaction. Chalcone is a common natural pigment and one of the important intermediaries in flavonoid biosynthesis [2].
What kind of chemical compound is a chalcone?
Chalcone is an aromatic ketone and an enone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones or chalconoids.
Which is the central core of a chalcone?
Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones. They show antibacterial, antifungal, antitumor and anti-inflammatory properties. They are also intermediates in the biosynthesis of flavonoids, which are substances widespread in plants…
What is the medicinal significance of chalcone ketones?
Synthesis and Medicinal Significance of Chalcones- A Review Chalcone is an aromatic ketone that forms a central core for a variety of important biologi- cal compounds, which are collectively known as chalcones.
How are the aromatic rings of a chalcone linked?
In chalcones, two aromatic rings are linked by an aliphatic three carbon chain. Chalcones (trans-1, 3-diaryl-2-propen-1-ones) are α, β-unsaturated ketones consisting of two aromatic rings (ring A and B) having diverse array of substituents.