What is congenic strain?
A congenic strain is an inbred strain that contains a small genetic region (ideally a single gene) from another strain, but which is otherwise identical to the original inbred strain.
What is speed congenics?
Our speed congenics program is essential for accelerating generational breeding in animal models that call for specific genetic predisposition. The time and money saved over traditional backcrossing breeding strategies will provide you with the competitive edge needed to distinguish your research.
What is the designation for offspring from the first backcross to generate a congenic strain?
outcross
In the derivation of any new congenic strain, the first cross is always an outcross, and the offspring are considered members of the F1 generation. The second cross is always a backcross, and the offspring are considered members of the N2 generation.
What are recombinant strains?
A recombinant inbred strain (or recombinant inbred line) is an organism with chromosomes that incorporate an essentially permanent set of recombination events between chromosomes inherited from two or more inbred strains.
What is inbred and outbred mice?
Genetically, there are two major classes of laboratory mice: inbred and outbred. Inbred mice are genetically homogeneous and there is very little variation or heterogeneity within a pure inbred strain. Outbred mice are bred specifically to maximize genetic diversity and heterozygosity within a population.
What does it mean to backcross mice?
Backcrossing is a two-generation breeding protocol that starts by generating hybrid F1 mice between two inbred strains (preferably distantly related), one of them carrying the mutation of interest. Then, F1 mice are mated with a member of one of the parental inbred strains to generate N2 mice.
What is GWAS used for?
Genome-wide association studies (GWAS) use high-throughput genomic technologies to scan entire genomes of large numbers of subjects quickly, in order to find genetic variants correlated with a trait or disease.
What recombinant means?
1 : relating to or exhibiting genetic recombination recombinant progeny. 2a : relating to or containing genetically engineered DNA. b : produced by genetic engineering recombinant bovine growth hormone.