Contents
- 1 What is the clonal selection theory of antibody formation?
- 2 What are the theories of antibody production?
- 3 What triggers clonal selection?
- 4 Which is the most significant among the theories of antibody production?
- 5 How did Frank Macfarlane Burnet change the theory of clonal selection?
- 6 What is the history of the clonal selection theory?
What is the clonal selection theory of antibody formation?
The clonal selection theory proposes that antigen selects lymphocytes for activation from a population of cells precommitted to produce specific antibody. Implicit in this theory is that antibody-forming cells are monospecific and express cell-surface receptors capable of binding foreign antigens.
What are the theories of antibody production?
Instructive theories suggests that an immunocompetent cell is capable of synthesizing antibodies of all specificity. The antigen directs the immunocompetent cell to produce complementary antibodies. According to these theories the antigen play a central role in determining the specificity of antibody molecule.
What is antibody formation?
Antibodies are produced by specialized white blood cells called B lymphocytes (or B cells). When an antigen binds to the B-cell surface, it stimulates the B cell to divide and mature into a group of identical cells called a clone. Antibodies attack antigens by binding to them.
What triggers clonal selection?
Clonal selection: The theory that lymphocytes bear antigen receptors before activation and that random mutations during clonal expansion cause the development of lymphocytes with high binding affinities for their antigens.
Which is the most significant among the theories of antibody production?
The clonal selection theory for the formation of antibodies is considered the most important discovery in immunology in the last 100 years.
How is clonal selection related to antibody production?
The clonal selection hypothesis states that an individual B cell expresses receptors specific to the distinct antigen, determined before the antibody ever encounters the antigen.
How did Frank Macfarlane Burnet change the theory of clonal selection?
In his paper “A Modification of Jerne’s Theory of Antibody Production using the Concept of Clonal Selection”, in the Australian Journal of Science, Dr Frank Macfarlane Burnet proposed that a large number of cells that can release antibodies already exist in the body and these cells are genetically designed to produce a unique antibody specificity.
What is the history of the clonal selection theory?
Historical insight: The clonal selection theory of antibody formation has recently been subjected to challenge from many quarters. A review of its history and that of scientific theories in general points to the importance of distinguishing between the central hypotheses of a theory and its subsidiary implications.
How is clonal selection related to immunogenic memory?
Clonality has important consequences for immunogenic memory. The clonal selection hypothesis states that an individual B cell expresses receptors specific to the distinct antigen, determined before the antibody ever encounters the antigen.
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