Contents
What type of drug is anakinra?
Anakinra is in a class of medications called interleukin antagonists. It works by blocking the activity of interleukin, a substance in the body that causes inflammation.
Is anakinra a biologic?
Anakinra is known as Kineret® and is an IL-1 inhibitor. It is part of a class of drugs called biologics.
What is anakinra made of?
Generic Name: anakinra Anakinra is a man-made form of a natural protein (interleukin-1 receptor antagonist) made by the body. It helps to block the effects of another protein (interleukin-1) which can cause joint pain/swelling/stiffness.
What does Kineret target?
Anakinra, sold under the brand name Kineret, is a biopharmaceutical medication used to treat rheumatoid arthritis, cryopyrin-associated periodic syndromes, familial Mediterranean fever, and Still’s disease. It is a recombinant and slightly modified version of the human interleukin 1 receptor antagonist protein.
Does anakinra suppress your immune system?
Kineret is an immunosuppressant that works by suppressing the immune system to prevent it from damaging tissues and joints. The immune system helps protect the body from harmful substances such as infectious agents and bacteria.
How long do you take anakinra?
Kineret may take some time to have an effect. For most people who experienced improvement with Kineret, results were seen within 3 months, but some patients continued to improve between 3 and 6 months after starting treatment. 1 Try not to get discouraged if you don’t see immediate results.
Why are biologics so expensive?
Biologic agents are more expensive to make than chemical drugs like DMARDs. The materials needed to create them cost more, and the manufacturing process, which uses live organisms, is more complex. The cost of research and development is higher, too. Biologics use technology called genetic modification.
Does Kineret make you tired?
Kineret side effects fever or chills; open sores on your body; or. signs of tuberculosis: fever, cough, night sweats, loss of appetite, weight loss, and feeling very tired.
What is the target of anakinra?
IL-1, one of the proinflammatory cytokines activated in CAPS, is the primary target for drugs such as anakinra. It was originally thought that anakinra should be used in the treatment of NOMID patients with CIAS1 mutations only.
What kind of drug is anakinra used for?
From Wikipedia, the free encyclopedia Anakinra (brand name Kineret) is a biopharmaceutical drug used to treat rheumatoid arthritis. It is a recombinant and slightly modified version of the human interleukin 1 receptor antagonist protein. It is marketed by Swedish Orphan Biovitrum.
How does anakinra block the activity of IL-1?
Anakinra (Kineret™) is an interleukin-1 (IL-1) receptor antagonist that blocks the biologic activity of naturally IL-1 by competitively inhibiting the binding of IL-1 to the Interleukin-1 type receptor.
How does taking Anakinra affect your risk of getting cancer?
Between one and ten percent of people have severe infections, decreased white blood cells, or decreased platelets. It is unclear if taking anakinra increases the risk of getting cancer; studies are complicated by the fact that people with rheumatoid arthritis are already at higher risk of getting cancer.
Is it safe to give Anakinra to pregnant women?
It was not tested in pregnant women, but appeared to be safe in animal studies. It should not be used in people who have active infections or latent tuberculosis, who have low white blood cells counts, or who are taking TNF inhibitors.