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Why is carboplatin dosed as AUC?
The FDA has recommended that physicians consider capping the dose of carboplatin for desired exposure (AUC) to avoid potential toxicity due to overdosing. The maximum dose is based on a GFR estimate that is capped at 125 mL/min for patients with normal renal function.
What is AUC carboplatin?
This carboplatin dosing calculator uses the Calvert method to calculate the total carboplatin dose needed to achieve a given AUC (area under the free carboplatin plasma concentration versus time curve) while taking into account renal function.
What is AUC chemo?
The most relevant pharmacokinetic parameter for drug exposure is the area under the curve (AUC) of plasma concentration x time following a single dose. During drug development, drug level sampling at multiple time points helps define the relationship between drug administration and the AUC.
How often should carboplatin be administered?
Carboplatin is typically given once every 3-4 weeks (every 21-28 days), but may occasionally be given weekly (every 7 days). The total number of treatments recommended will vary based on your clinical circumstances, but an initial plan will be outlined for you by your doctor.
How is AUC calculated?
The AUC can be computed by adjusting the values in the matrix so that cells where the positive case outranks the negative case receive a 1 , cells where the negative case has higher rank receive a 0 , and cells with ties get 0.5 (since applying the sign function to the difference in scores gives values of 1, -1, and 0 …
How is the carboplatin AUC and dosage calculated?
■ Carboplatin dose based on the Calvert formula is: Dosage = Target AUC x (GFR + 25) Carboplatin and target AUC The carboplatin dosage value is calculated by taking into account the target area concentration versus time curve and estimated GFR.
What does the AUC stand for in chemotherapy?
The calvert formula is used to determine the dose of chemotherapy drugs such as 5-fluorouracil and carboplatin. AUC is a quick measure of how much of the drug an individual has been exposed to in a given amount of time. Keeping the AUC within a defined range helps limit the dangerous side effects of chemotherapy.
How is the Calvert formula used to calculate AUC?
In this article, the development and application of a simple equation, known as the Calvert formula, are discussed. This formula can be used to calculate the carboplatin dose accurately in order to obtain a target AUC by using only the GFR. The formula is: dose (mg) = AUC (mg ml-1 min) x [GFR (ml/min) + 25 (ml/min)].
Which is more accurate, carboplatin GFR or AUC?
5) AUC-based carboplatin dosing is more accurate than dosing according to BSA. 6) Several factors must be considered in addition to the GFR to determine the precise dosage. Additional factors that should be assessed include: previous exposure to chemotherapy or radiotherapy, and overall health status.