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Why is methimazole preferred over propylthiouracil?
Methimazole — Methimazole is usually preferred over propylthiouracil because it reverses hyperthyroidism more quickly and has fewer side effects. Methimazole requires an average of six weeks to lower T4 levels to normal and is often given before radioactive iodine treatment. Methimazole can be taken once per day.
Is methimazole the same as PTU?
In the US, there are two antithyroid medications available—propylthiouracil (PTU) and methimazole (also known as Tapazole). The medications are similar, as they both stop the thyroid from producing T3 and T4 hormones.
Why the propylthiouracil is preferred over methimazole in pregnancy?
“PTU had always been the preferred treatment in pregnancy over methimazole in the United States because it was thought from early studies that it did not cross the placenta to the same extent as methimazole.
What is effect on baby if mother is hyperthyroidism?
Uncontrolled hyperthyroidism has many effects. It may lead to preterm birth (before 37 weeks of pregnancy) and low birth weight for the baby. Some studies have shown an increase in pregnancy-induced hypertension (high blood pressure of pregnancy) in women with hyperthyroidism.
Which is better for hyperthyroidism PTU or methimazole?
Transaminase elevations and leukopenia occurred less commonly with both doses of methimazole than with PTU. Rash was less common with lower-dose methimazole than with higher-dose methimazole or PTU. Nakamura H et al. Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves’ disease.
Which is better, methimazole or propylthiouracil?
Antithyroid drugs: methimazole & propylthiouracil 1 I. The curative effect. MMI 5mg is equivalent to PTU 50mg drug dose, but related studies have found that, although the dose is equivalent, the efficacy is not the same 2 II. Adverse reactions. 3 2. Liver damage. 4 III. Special circumstances 5 1. Pregnant patients. …
Which is better MMI 5mg or PTU 50MG?
MMI 5mg is equivalent to PTU 50mg drug dose, but related studies have found that, although the dose is equivalent, the efficacy is not the same in clinical application of hyperthyroidism. The study believes that the therapeutic effect of MMI is better than PTU, we explain from the following aspects:
Which is better for FT4 MMI or PTU?
When patients were divided into two groups by initial FT4, in the group of the patients with severe hyperthyroidism (FT4, 7 ng/dl or more, 64 patients) MMI 30 mg/d normalized FT4 more effectively than PTU 300 mg/d at 8 and 12 wk and MMI 15 mg/d at 8 wk, respectively ( P < 0.05).