Contents
- 1 What is Spatulation process?
- 2 What is the difference between trituration and Levigation?
- 3 What is geometrical mixing?
- 4 What equipment is used in pharmacy?
- 5 What is a levigating agent?
- 6 What is the medical dictionary definition of spatulation?
- 7 How are powders formulated in the compounding laboratory?
What is Spatulation process?
[spach″u-la´shun] the combining of materials into a homogeneous mixture by continuously heaping them together and smoothing the mass out on a smooth surface with a spatula.
What is pharmacy trituration?
A trituration is a dilution of a potent drug powder with an inert diluent powder, usually lactose, in a definite proportion by weight. We can then remove a weighable portion (aliquot) of the mixture containing the desired quantity of substance to maintain an acceptable range of accuracy.
What is the difference between trituration and Levigation?
Trituration is the continuous rubbing or grinding of the powder in a mortar with a pestle. Levigation reduces the particle size by triturating it in a mortar or spatulating it on an ointment slab or pad with a small amount of a liquid in which the solid is not soluble.
What is geometric mixing in pharmacy?
Geometric dilution is a pharmaceutical process that thoroughly mixes a small amount of a drug with an appropriate amount of a diluent, an inert substance that thins or binds the drug. It ensures equal distribution of the drug throughout the resulting compound, according to the UNC Eshelman School of Pharmacy.
What is geometrical mixing?
When mixing a small amount of a drug with a large amount of another ingredient or diluent, the process of geometric dilution is used. In this method the drug present in smaller quantity is placed in the mortar with an equal amount of the other ingredient. The two materials are triturated until they are well mixed.
Which method is used for mixing of powder?
The trituration process involves direct rubbing or grinding of hard powder in a mortar and pestle. The trituration method is used for both pulverization and mixing.
What equipment is used in pharmacy?
It also includes scales, flasks, beakers, graduated cylinders, spatulas, IV materials, vials, syringes, and needles. Compounding also requires personal protective equipment (PPE), such as gloves, goggles, and masks that protect the pharmacist and the drug materials from each other.
What is Trituration used for?
In organic chemistry, trituration is a process used to purify crude chemical compounds containing soluble impurities. A solvent is chosen in which the desired product is insoluble and the undesired by-products are very soluble or vice versa.
What is a levigating agent?
LEVIGATING AGENTS The liquid, called a levigating agent, is somewhat viscous and has a low surface tension to improve ease of wetting the solid. Levigating agents act as lubricating agents. They make incorporating solids easier, and they usually give smoother preparations.
What is API in pharmacy?
Active Pharmaceutical Ingredients i.e., API refers to an active ingredient that is contained in the medication. For instance, the active ingredient for relieving pain is incorporated in the painkiller. It is called API.
What is the medical dictionary definition of spatulation?
[ spach″u-la´shun] the combining of materials into a homogeneous mixture by continuously heaping them together and smoothing the mass out on a smooth surface with a spatula. Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc.
What kind of blade is a spatula used for?
A flat blade, like a knife blade but without a sharp edge, used in pharmacy for spreading plasters and ointments and as an aid to mixing ingredients with a mortar and pestle. [L. dim. of spatha, a broad, flat wooden instrument, fr. spatula.
How are powders formulated in the compounding laboratory?
can be made into many different dosage formulations (capsules, tablets, powders for reconstitution, dusting powders, bulk powders, powders for inhalation, etc.) Pharmaceutical powders are formulated to be exist as fine particles. The powders are then smooth to the touch and nonirritating to the skin.
How is a trituration used in a compounding laboratory?
A trituration is a dilution of a potent drug powder with an inert diluent powder, usually lactose, in a definite proportion by weight. We can then remove a weighable portion (aliquot) of the mixture containing the desired quantity of substance to maintain an acceptable range of accuracy.